CONFIRMED: PhD Dissertation Proposal Defense by Cem Celik: "Photochemical Synthesis of Unnatural Amino Acids and Their Genetically Encoded Incorporation into Proteins in Live-Cells"
Title: Photochemical Synthesis of Unnatural Amino Acids and Their Genetically Encoded Incorporation into Proteins in Live-Cells by Cem Celik Date: Wednesday, December 11, 2024 Time: 2pm Abstract: Unnatural amino acids (UAAs) are widely used in chemical biology and medicinal chemistry; however, their syntheses are still quite challenging as the current synthetic procedures involve multiple steps with low-yielding and are environmentally unfriendly. My dissertation research focuses on developing a new photochemical method for efficient synthesis of unnatural amino acids and exploring their applications in incorporating proteins in live-cells. This research develops an efficient novel photochemical CCUAA method for synthesis a broad range of unnatural amino acids with varied properties, which may find broad applications in chemical biology research and medicinal industry. Their protein incorporation enables novel bio-imaging and other technologies that will have a significant impact on fundamental and applied research by shedding light on unknown cellular functions, networks, processes, and modifying such processes. PhD Dissertation Committee: Dr. Maolin Guo (Advisor) Dr. Catherine Neto (Chemistry) Dr. Shuowei Cai (Chemistry) Dr. Katrina Velle (Biology) Join Zoom Meeting: https://umassd.zoom.us/j/99388959356?pwd=ZwtfQGWXaba50bA6jDqFYx2pqZubTw.1 Meeting ID: 993 8895 9356 Passcode: 238584
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