CONFIRMED: BMEBT MS Thesis Proposal Presentation by Andrew Medeiros - Investigation of Irisin on Osteocyte Cell Behavior
Location: TEX 219 Abstract: This research explores the impact of type 2 diabetes (T2DM) on bone health, focusing on how hyperglycemia contributes to increased bone fragility through the action of bone cells. Despite many T2DM patients having normal to high bone mineral density, they exhibit elevated fracture risks, suggesting that bone quality rather than quantity is affected. The study aims to investigate the role of advanced glycation end-products (AGEs), crosslinks that accumulate in diabetic conditions to alter bone metabolism and ultimately impact bone quality. AGEs disrupt bone turnover by affecting bone cell function. Given that AGEs have harmful impacts on bone, our study will examine irisin, a myokine that may inhibit AGEs and promote bone growth. Through in vitro experiments using osteocyte cells in hyperglycemic conditions, we will assess cell viability, gene expression, and the potential of irisin to counteract the negative effects of AGEs on osteocytes. This work could lead to novel therapies that improve bone quality and reduce fracture risk in T2DM patients. Advisor: Dr. Lamya Karim, Dept. of Bioengineering Committee Members: Dr. Tracie Ferreira, Dept. of Bioengineering Dr. Laura Hanzly, Dept. of Bioengineering All BMEBT graduate students are encouraged to attend, and all interested parties are invited.
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Bioengineering Department
508.999.8199
tferreira@umassd.edu