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faculty
Lamya Karim, PhD
Associate Professor
Bioengineering
Contact
508-999-8560
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Education
| 2011 | Rensselaer Polytechnic Institute | PhD in Biomedical Engineering |
| 2007 | Stony Brook University | BE in Biomedical Engineering |
Teaching
- Biomechanics
- Mechanobiology
- Biomedical Devices
Teaching
Programs
Programs
- Bioengineering BS, BS/MS
- Biomedical Engineering
- Biomedical Engineering and Biotechnology MS, PhD
- Engineering and Applied Science PhD
Teaching
Courses
Written presentation of an original research topic in biomedical engineering and biotechnology, which demonstrates the knowledge and capability to conduct independent research. The thesis shall be completed under the supervision of a faculty advisor. An oral examination in defense of the thesis is required.
Written presentation of an original research topic in biomedical engineering and biotechnology, which demonstrates the knowledge and capability to conduct independent research. The thesis shall be completed under the supervision of a faculty advisor. An oral examination in defense of the thesis is required.
A culminating experience in which the student synthesizes his/her course knowledge and experimental skills into a brief but detailed experimental study, which also involves cross-field interdisciplinary cooperation. Although in some cases this project may be done individually under the supervision of one faculty member, it is expected that students will join in a team-based, collaborative effort involving students from a number of different disciplines, post-doctoral fellows and industry representatives and with intercampus participation.
Introduction to the biotransport phenomena in biomanufacturing systems and unit operations. Emphasis is placed on principles and applications of fluid and mass transport processes in bioreactors, cell, tissue and organ systems. Topics include fundamentals of diffusion and mass transport in and out of cells, immobilized catalysts and biofilms; principles and significance of chemical and biochemical reaction kinetics; and fluid and mass transport in pipes and culture vessels, as well as organs and medical and diagnostic devices.
Introduction to the mechanical behavior of biological tissues and systems. Specific topics include: structure and function of biological tissues, mechanical properties of natural and prosthetic materials, and analysis of both rigid body and deformational mechanics applied to biological tissues including bone and soft connective tissues. Basic concepts of deformable body mechanics, including stress and strain analysis, viscoelasticity, muscle action and applications to common problems in orthopedic biomechanics.
Introduction to the mechanical behavior of biological tissues and systems. Specific topics include: structure and function of biological tissues, mechanical properties of natural and prosthetic materials, and analysis of both rigid body and deformational mechanics applied to biological tissues including bone and soft connective tissues. Basic concepts of deformable body mechanics, including stress and strain analysis, viscoelasticity, muscle action and applications to common problems in orthopedic biomechanics.
Mechanical regulation of biological systems. Topics include basic concepts of mechanobiology; embryogenesis & histogenesis of tissues with particular reference to the skeletal system; mechanical forces at cellular, tissue and organ level; mechanical regulation of cellular behavior, tissue growth, and organ development; limits of mechanical regulation; biochemical influences; and applications of mechanobiology to tissue regeneration.
This course is a discussion of design of biomedical engineering devices and systems, laws and regulations applied to medical product development, manufacturing, testing, marketing, and post-marketing surveillance. This course provides an overview of regulatory affairs related to biomedical devices and a foundation to understand the regulations based on the US FDA requirements.
Mechanical regulation of biological systems. Topics include basic concepts of mechanobiology; embryogenesis & histogenesis of tissues with particular reference to the skeletal system; mechanical forces at cellular, tissue and organ level; mechanical regulation of cellular behavior, tissue growth, and organ development; limits of mechanical regulation; biochemical influences; and applications of mechanobiology to tissue regeneration.
This course is a discussion of design of biomedical engineering devices and systems, laws and regulations applied to medical product development, manufacturing, testing, marketing, and post-marketing surveillance. This course provides an overview of regulatory affairs related to biomedical devices and a foundation to understand the regulations based on the US FDA requirements.
Research
Research awards
- $ 41,800 awarded by Massachusetts General Hospital | NIH for Pilot Awards Subproject Fund
- $ 2,577 awarded by Montana State University for AGE Assessment for Germ Free Study
Research
Research interests
- Biomechanics
- Mechanobiology
- Orthopedics
- Skeletal health
- Bone cell biology
Skeletal fragility in patients with type 2 diabetes is a growing public health issue. The prevalence of diabetes is increasing rapidly, and diabetics have three times greater fracture risk compared to non-diabetics. The causes of diabetic skeletal fragility are not well established, which makes it difficult for clinicians to make decisions regarding fracture prevention in this population. Numerous micro-scale changes may contribute to skeletal health issues in these patients. For instance, changes in bone matrix composition due to accumulation of non-enzymatic chemical crosslinks can lead to poor bone quality and in turn deteriorate bone’s mechanical integrity. These crosslinks can also lead to an increase in the formation of micro-scale damage within bone. Further, some patients have altered bone microarchitecture that could contribute to their increased fracture risk, and these microarchitectural changes may result from altered bone cell behavior. Thus, we aim to investigate the biomolecular and cellular mechanisms of skeletal fragility in diabetes and other major clinical conditions. The ultimate goal of our research is to help improve diagnostic methods for fracture risk assessment and clinical management of patients at risk for fracture.